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We blog about genomics. We also make a platform for open-source analysis of next generation data in the cloud. Hello.

RNA-Seq Interactive Literature Review

Kate Blair

Featured, Science

RNA-Seq is fast becoming the top method for examining the transcriptional activity of genomes. In the five years since the first publications described the technology, RNA-Seq has enabled the discovery of new transcripts in well-studied genomes, challenged our views of imprinting, offered insights into the biology of cancer, and transformed new

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Short read alignment: seeding

Nate

Science

In my last post I explained some of the basics of short read alignment algorithms. Go read it if you like; if not, recall that: Many modern alignment algorithms rely on what is called seeding and extending. “Seeding” is finding exact matches of part of the read with part of the

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Short read alignment: an introduction

Nate

Science

Biologists today often find themselves with lots of–say, 10^6–short sequences of DNA from a sample, and their ability to do scientifically useful things with those sequences depends on their ability to align those sequences to a reference sequence. Many of the hard and important projects in genomics either are alignment

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Unicorn genome sequence announced

brandi

Featured, Science

A landmark genome announcement was made by the Equid Sequencing Consortium today. Scientists hope that the new data will explain origins of the horn and help identify key genes that drive horn development. A high-quality draft of unicorn genome was published today and will be submitted to GenBank later this spring.

Visualizing exome coverage depth

Nate

Product News

The coverage of a base pair in a sequencing run is the number of times that it was sequenced. We usually estimate coverage in an intuitive way: by comparing the total amount of measurement to the total amount of stuff to be measured. Dividing the total length of the reads

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RNA-Seq: The first wave of papers

Kate Blair

Science

A flurry of papers in May of 2008 introduced the world to RNA-Seq. This new technology provided a higher resolution picture of transcription than was possible ever before. Nearly five years on, we look back at the publications that upset the microarray industry and sent tweed-clad professors scrambling for the

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American Society for Human Genetics 2012

Nate

Conferences, Featured

We will be in San Francisco for the annual meeting of the American Society for Human Genetics next week, Nov. 6 – 10. Stop by our booth 1204, say hello, and pick up a copy of our latest pipeline comparisons for exome variant calling. See you in San Francisco!

We are always engaged in research and development, working to build the future of genomics, science, and health. Let’s work together. We’d love to hear about your projects and challenges, so drop us a line.

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