Blog

We blog about genomics. We also make a platform for open-source analysis of next generation data in the cloud. Hello.

Algorithms for Bioinformaticians

Nate

Uncategorized

One opportunity that comes from working in an infant discipline is that of being able to examine and influence its basic tools. You are more likely to fundamentally improve alignment or assembly than you are to improve the foundations of thermodynamics. And given the state of bioinformatics software, it is

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Ion Proton RNA-Seq: in search of the best alignment method

Kate Blair

Science

Each sequencing technology comes with a unique and unavoidable error profile due to the chemistry, biology, and hardware involved [1,2,3]. If we want avoid analysis artifacts and arrive safely at the biological reality underlying the data, we must to account for these errors during informatic analysis. Recently, researchers have begun tackling

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World Economic Forum: Technology Pioneers are Boston Strong

carol

Featured

With less than a week until Super Bowl XLVIII in New Jersey, we’re taking a look at a different meeting of elites. We’re not talking about Peyton Manning, and we’re certainly not talking about Russell Wilson. Instead, we’re focusing our attention on the World Economic Forum’s Annual Meeting, which took

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Seven Bridges talks genomics with MongoDB and AstraZeneca

carol

Conferences

  Our CEO, Deniz Kural, recently joined Jason Tetrault, Architect at AstraZeneca Pharmaceuticals, for a panel discussion of topics in genomics and pharmaceuticals in an event hosted by MongoDB. Before the panel, Jason gave what he described as a “fairly inaccurate overview of genetics processing” from the sequencer to the

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Microsoft Research CABI 2013

Nate

Conferences

This Monday we went to Microsoft’s beautiful NERD building for Microsoft Research’s 2013 conference in Computational Aspects of Biological Information (CABI). The pastries were good and the presentations were even better. Jim Collins spoke about implementing flip-flops in bacteria, and about the prospects of biocomputation more generally; Pardis Sabeti discussed

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The GTEx methods debate

Kate Blair

Featured, The Future of Work

This week, a dialogue erupted around the Genotype-Tissue Expression (GTEx) Consortium and its methods for analyzing RNA-Seq data. Tracking the debate will take you through Twitter threads, into blog posts, down comments sections, past PubMed entries, and over Nature‘s login wall.

A mystery muscle lincRNA

Nate

Science

We know that our whole genome is distributed to (almost) every cell of our bodies. This fact can be used both to surprise introductory biology students and to usefully refine a fundamental scientific question. Instead of merely asking how it comes to be that different parts of our bodies have

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We are always engaged in research and development, working to build the future of genomics, science, and health. Let’s work together. We’d love to hear about your projects and challenges, so drop us a line.

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