Blog

We blog about genomics. We also make a platform for open-source analysis of next generation data in the cloud. Hello.

How Memoization Enhances Efficiency for Large Scale Genomic Analysis Research Projects

Memoization for large scale genomic analysis allows researchers and bioinformaticians to restart from a point of failure by enabling the reuse of existing outputs. This functionality is of critical importance given the size and complexity of genomic data and the impact of a failure on workflow efficiency and overall cost. …

Written by The Seven Bridges Computation Team

How Computational Workflows for Genomic Analysis can be Simplified

Computational workflows are often not just computational workflows. Most interface with Library Information Management Systems (LIMS), Next-generation Sequencing (NGS) instruments, perform complex input validations, and coordinate processing between on-prem and cloud services. Many developers find that writing the code and software required to perform these integrations to be a daunting …

Written by Kaushik Ghose

BioCompute and Its Importance in Accelerating Market Access for New Drugs

The prevalence of NGS data within regulatory submissions has skyrocketed over the past few years which has prompted a collaboration amongst the Food and Drug Administration (FDA) and George Washington University to develop the BioCompute Object (BCO) as a standard for communicating NGS data. The BioCompute Object community aims to …

Written by Christian French

Neoantigen Discovery Using Next-Generation Sequencing Data

Leveraging neoantigens for guided treatment has become the definition of personalized cancer immunotherapy. Given their potential to eradicate nonspecific treatments such as chemotherapy, a host of therapeutic studies are underway to further understand how neoantigens can be used to trigger immunity-induced tumor regression. Seven Bridges has developed a workflow for …

Written by Vladimir Kovacevic

Biomedical Datasets for Large Scale Analysis

Biomedical data is growing at astonishing rates with the broadening of access to next-generation sequencing (NGS) and single-cell solutions. Not only is more data being generated, but it is also being generated with improvements in base-calling accuracy, read length and the generation of reads from each end of the library …

Written by Manisha Ray

Pan-Genome Analysis Takes Center Stage

The concept of a pan-genome reference is straightforward: a reference structure that represents all the known genetic variation for a particular population or species. The representation of the human reference genome as a linear haploid DNA sequence poses limitations when trying to incorporate the known genetic diversity of human populations. …

Written by Devin Locke

Sentieon Multi-instance Whole Genome Workflow

Organizations have adopted the use of Next Generation Sequencing (NGS) as a one of the primary tools of their discovery, diagnostic and clinical efforts. Simultaneously — the number of tools available for NGS analysis has ballooned, with each tool having different capabilities for speed, accuracy, cost, etc. Seven Bridges offers …

Written by Vladimir Kovacevic, Ana Popic, Luka Topalovic, Milan Kovacevic, Aleksandar Minic, Stefan Risteski

Data Cruncher Public Interactive Analyses

We are excited to announce a suite of public interactive analyses readily available for researchers to use with their own data. Data Cruncher Interactive Analyses is a public project created with the goal of enhancing end-to-end bioinformatics analysis on the Platform. The suite is currently comprised of five interactive analyses …

Written by Marko Milanovic, Nemanja Vucic, Milan Kovacevic, Boris Majic & Ana Damljanovic

Taxonomic profiling of metagenomics samples: Get to know your loyal residents

Numerous colonies of different organisms live virtually everywhere on Earth, even in and on our bodies. They are called microbes and we all know about them. But do we really? Actually, the human race knew nothing about microbes before the 17th century. There were some assumptions and hypotheses, but their …

Written by Aleksandar Danicic, Nemanja Vucic, Srdjan Kasapovic and Vesna Pajic

We are always engaged in research and development, working to build the future of genomics, science, and health. Let's work together. We'd love to hear about your projects and challenges, so drop us a line. get in touch