We blog about genomics. We also make a platform for open-source analysis of next generation data in the cloud. Hello.

The GA4GH Workflow Execution Challenge: evaluating reproducibility and portability across platforms

Large-scale, geographically distributed genomics analysis efforts, such as the PanCancer Analysis of Whole Genomes (PCAWG) project, highlight a trend in our community towards moving compute to where data resides. For PCAWG, this was out of necessity as the genomes for ~2,800 cancer donors were stored across 8 different locations around …

Written by Guest Author: Brian O’Connor

Sequence Bloom Trees, Part I: Motivation and principles

Modern bioinformatics involves a lot of searching datasets, like The Cancer Genome Atlas (TCGA), that contain data from many experiments. Wanting to do this efficiently raises not only data management problems but also algorithmic ones. Searching a dataset like TCGA in hopes of figuring out which experiments contain a given …

Written by Nate

Identifying viral sequences in TCGA data using Kraken and Centrifuge

Image adapted from Kim et al. Genome Res. 26, 1721–1729 (2016). Next-Generation Sequencing has opened up the field of metagenomics. In metagenomic studies, a sample often contains a complex ecosystem of different microorganisms. The key challenge in these experiments is disentangling the identities of unknown species from millions of sequencing reads. Bioinformatic tools for metagenomics are designed to […]

Written by Patrick

Reference bias: Challenges and solutions

Ahead of the Bio-IT World Conference & Expo in Boston this week, we take a look at the role of reference genomes in ensuring accurate genomic analysis. In standard next-generation sequencing analyses, DNA is fragmented and sequenced. The sequenced reads are then aligned to a reference genome for the species. …

Written by Jessica Lau

Festival of Genomics: Reflecting on graph genomes

Yesterday at Festival of Genomics, London, Seven Bridges CEO Deniz Kural joined a panel discussing implementations of graph genomes, alongside Erik Garrison from the Wellcome Trust Sanger Institute and Andy Yates from EMBL-EBI. Great panel talking about #graph #genomes at #GenomicsFest @erikgarrison @denizkural Andrew Yates @FLGenomics — Adrian Alexa …

Written by Nick

Bioinformatics applications in cancer immunotherapy

An emerging characteristic, or hallmark, of cancer cells is their ability to evade destruction by the immune system. While immune surveillance plays a role in controlling tumorigenesis and tumor progression, cancer cells can in turn disable the immune system by secreting immunosuppressive factors or recruiting immunosuppressive cells. Because of this …

Written by Jessica Lau

The race for a revolutionary new cancer diagnosis tool: The Blood Profiling Atlas in Cancer

A revolutionary approach to cancer diagnosis Liquid biopsy, a new technique for tracking down fragments of tumor DNA in the blood, has the potential to revolutionize how cancer is diagnosed and treated. At next week’s Precision Medicine World Congress, Seven Bridges’ Bruce Press will lead the “Update on the Cancer …

Written by Patrick

Cancer Cell Line Encyclopedia — Five Key Discoveries

Powered by a wave of next generation sequence data from labs and the clinic, oncology is in the midst of a paradigm shift towards personalized medicine. To the modern cancer biologist, the genomic and transcriptomic features of a patient’s tumor have the potential to function as key guideposts for selecting …

Written by Patrick

Launching the next DREAM Challenge on the Seven Bridges Cancer Genomics Cloud

The explosion in biomedical data requires ongoing development of analysis methods and community standards. A proven way of driving innovation is through Challenges—competitions to develop crowdsourced methods to answer specific scientific questions. These challenges offer unique opportunities for academic and commercial communities to advance science by developing precise algorithms and …

Written by Nick

We are always engaged in research and development, working to build the future of genomics, science, and health. Let's work together. We'd love to hear about your projects and challenges, so drop us a line.

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