We blog about genomics. We also make a platform for open-source analysis of next generation data in the cloud. Hello.

Short read alignment: seeding

In my last post I explained some of the basics of short read alignment algorithms. Go read it if you like; if not, recall that: Many modern alignment algorithms rely on what is called seeding and extending. “Seeding” is finding exact matches of part of the read with part of the …

Written by Nate

Short read alignment: an introduction

Biologists today often find themselves with lots of–say, 10^6–short sequences of DNA from a sample, and their ability to do scientifically useful things with those sequences depends on their ability to align those sequences to a reference sequence. Many of the hard and important projects in genomics either are alignment …

Written by Nate

Seven Bridges Platform wins BioIT World Best of Show

We’ve been working pretty hard over the past few years to build a tool for next generation sequence data analysis that we love. So we were very pleased to see Seven Bridges Platform win Best of Show in the Informatics Data & Tools division at BioIT World 2013. Seven Bridges …

Written by Kate Blair

Unicorn genome sequence announced

A landmark genome announcement was made by the Equid Sequencing Consortium today. Scientists hope that the new data will explain origins of the horn and help identify key genes that drive horn development. A high-quality draft of unicorn genome was published today and will be submitted to GenBank later this spring.

Written by brandi

Visualizing exome coverage depth

The coverage of a base pair in a sequencing run is the number of times that it was sequenced. We usually estimate coverage in an intuitive way: by comparing the total amount of measurement to the total amount of stuff to be measured. Dividing the total length of the reads …

Written by Nate

Cloud-based NGS analysis makes it to Nature

You know a technology has made it when it shows up in a print page of Nature. So we were pleased to see that Vol. 495, Issue 293, released today, includes a piece on the rise of cloud-based next-generation sequence (NGS) analysis. The past year of conferences has given us …

Written by Kate Blair

RNA-Seq: The first wave of papers

A flurry of papers in May of 2008 introduced the world to RNA-Seq. This new technology provided a higher resolution picture of transcription than was possible ever before. Nearly five years on, we look back at the publications that upset the microarray industry and sent tweed-clad professors scrambling for the …

Written by Kate Blair

AWS Global Start-Up Challenge Semi Finals

It is official: we are in the semi-finals. With competitors ranging from business applications to gaming to big data and high-performance computing, we are proud to be among such great company!

Written by Nate

American Society for Human Genetics 2012

We will be in San Francisco for the annual meeting of the American Society for Human Genetics next week, Nov. 6 – 10. Stop by our booth 1204, say hello, and pick up a copy of our latest pipeline comparisons for exome variant calling. See you in San Francisco!

Written by Nate

We are always engaged in research and development, working to build the future of genomics, science, and health. Let's work together. We'd love to hear about your projects and challenges, so drop us a line. get in touch