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We blog about genomics. We also make a platform for open-source analysis of next generation data in the cloud. Hello.

Graph Genome

Accurate sequencing data analysis for under-represented populations: The Pan-African genome

We are excited to announce the release of our GRAF Population Solution, a set of tools, services, and workflows  that enable the construction of genome graph references for targeted populations and/or studies. In this blog post, we discuss some of the advantages of population-specific graphs compared to  methods that rely …

Written by Deniz Turgut, Kübra Narcı, Güngör Budak, H. Serhat Tetikol, and Seven Bridges GRAF Team
Graph Genome

Pan-Genome Graphs Help Identify SNPs, INDELs and Structural Variants with Higher Accuracy

Improved methods for analyzing next-generation sequencing (NGS) data is mission critical given inherent flaws with the current human genome linear reference. Building on years of experience developing pan-genome references to eliminate reference bias, Seven Bridges GRAF is now broadly available to researchers on all Seven Bridges platforms.  The next-generation Seven …

Written by H. Serhat Tetikol, Amit Jain, Seven Bridges GRAF Team
Graph Genome

Pan-Genome Analysis Takes Center Stage

The concept of a pan-genome reference is straightforward: a reference structure that represents all the known genetic variation for a particular population or species. The representation of the human reference genome as a linear haploid DNA sequence poses limitations when trying to incorporate the known genetic diversity of human populations. …

Written by Devin Locke
Conferences

Reference bias: Challenges and solutions

Ahead of the Bio-IT World Conference & Expo in Boston this week, we take a look at the role of reference genomes in ensuring accurate genomic analysis. In standard next-generation sequencing analyses, DNA is fragmented and sequenced. The sequenced reads are then aligned to a reference genome for the species. …

Written by Jessica Lau
Graph Genome

Festival of Genomics: Reflecting on graph genomes

Yesterday at Festival of Genomics, London, Seven Bridges CEO Deniz Kural joined a panel discussing implementations of graph genomes, alongside Erik Garrison from the Wellcome Trust Sanger Institute and Andy Yates from EMBL-EBI. Great panel talking about #graph #genomes at #GenomicsFest @erikgarrison @denizkural Andrew Yates @FLGenomics pic.twitter.com/4Cxy2CslvT — Adrian Alexa …

Written by Nick

We are always engaged in research and development, working to build the future of genomics, science, and health. Let's work together. We'd love to hear about your projects and challenges, so drop us a line.

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