Science February 3rd, 2014 Ion Proton RNA-Seq: in search of the best alignment method Each sequencing technology comes with a unique and unavoidable error profile due to the chemistry, biology, and hardware involved [1,2,3]. If we want avoid analysis artifacts and arrive safely at the biological reality underlying the data, we must to account for these errors during informatic analysis. Recently, researchers have begun tackling … Written by Kate Blair Science October 22nd, 2013 Better sequences (and fewer homopolymer errors) for Ion Torrent The short read files that Ion Torrent’s sequencing machines give us still contain many homopolymer errors: errors in the number of bases called when a single nucleotide occurs more than once in sequence. This makes alignment harder and drowns real indels in a sea of noise. These homopolymer errors arise … Written by Nate